lunchThere are always exciting research opportunities awaiting and positions available in our laboratory at technician, graduate student and postdoctoral levels. Below we have summarized the major projects ongoing in the laboratory. Information on applying is at the end of this section.

Direct transmission electron microscopy has always been a powerful means of studying DNA and DNA-protein complexes. In the past it provided the first demonstration of supercoiling of DNA, was used to discover RNA splicing, to reveal the nucleosome, and to show how DNA is bent by phased tracts of adenines. More recently it was used to discover that telomeres are arranged into loops. This technology is more and more in demand as molecular biology studies across the world are moving toward understanding how complex DNA-protein machines are built and drive fundamental reactions in replication, transcription, and repair. Our laboratory has pioneered these methods and developed ways of combing this information with parallel biochemical studies. Students and fellows in our laboratory thus gain training which is unique both in the EM methods and in solid DNA-protein biochemistry. This has placed them in a particularly advantageous position in their career development.

Graduate Student positions. Frequently foreign students ask if it is possible to directly apply to an individual laboratory for admission. At the University of North Carolina, this is not possible. Students must be admitted through one of nearly a dozen different graduate programs. Once the student has been admitted, then he or she is able to select from many different laboratories in the departments of Genetics and Molecular Biology, Biochemistry, Microbiology and Immunology, Pathology, Cell Biology, and Pharmacology among others. Information about application can be found on the UNC Graduate Web Page:

Technician Positions. We frequently have openings for technicians in the laboratory. Strong preference is given to candidates with tissue culture or DNA cloning experience. In general at least 1 year of full time laboratory experience in the US or a masters degree is required. Technicians are treated as equal members of the laboratory and are expected to present their work in the weekly laboratory meetings and are frequently sent to national meetings. Their names are included on papers when they have made a substantial contribution to the work. Queries should be sent to the email address at the end of this section or by mail to Dr. Griffith at the Lineberger Comprehensive Cancer Center, 450 West Drive, Chapel Hill, NC 27599.

Postdoctoral Positions. We are presently seeking fellows to join our laboratory in each of our major research topics described below. Salaries generally follow the NIH scale. The research environment at the Lineberger Comprehensive Cancer Center is superb with special seminar programs and retreats for fellows, as well as tutorials on grant writing and how to apply for faculty positions. Each fellow works on a specific project of his/her own and one which does not compete with projects of other laboratory members. Because we are always engaged in collaborations with other laboratories in the US and abroad, fellows are involved in one or more of these collaborations. This provides contacts with other groups, and provides additional publication opportunities to further build a resume.
The living environment. The Research Triangle area provides one of the most attractive areas to live in the US with costs of housing, utilities, food, and car insurance lower than it is in the large urban areas. Quality apartments close to UNC can be found for $650/month for a one bedroom apartment. Frequently fellows are able to live close enough to take a bus or bicycle to the lab. There are many recreational activities including water sports on the nearby Jordan Lake, horse riding, bicycling, and numerous cultural activities at UNC, Duke and in Raleigh. More information can be found at ( Application for a position in our laboratory is described at the end of this section.